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Reconstitution requires bacteriostatic water containing benzyl alcohol as an antimicrobial preservative

However, two large meta-analyses of RCTs concerning T2D did not show any significant risk for atrial and ventricular arrhythmias or sudden cardiac death associated with GLP-1RAs

Griffin JH, Zlokovic BV, Mosnier LO

Maiti A, DiNardo CD, Rausch CR, Cortes JE, Pemmaraju N, Daver NG, Ravandi F, Garcia-Manero G, Borthakur GM, Naqvi K, Ohanian MN, Short NJ, Alvarado Y, Benton CB, Kadia TM, Takahashi K, Yilmaz ME, MD, Jain N, Kornblau SM, Sasaki K, Andreeff M , Bose P, Ferrajoli A, Issa GC, Jabbour E, Masarova L, Rytting ME, Thompson PA, Wang SA, Konoplev S, Chen Z, Goswami M, Maduike R, Guerrero JA, Zhang Q, Cavazos A, Ma H, Bivins CA, Wade A, Adewale SL, Tse S, Thomas R, Vaughan K, Pierce SA, Ning J, Qiao W, Welch JS, Kantarjian HM, Konopleva MY

When delivered transdermally (on the skin), it is difficult for the skin to absorb fully